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In addition to these three main types of titanium dioxide, there are also specialized grades that have been developed for specific applications. For example, there are grades of titanium dioxide that have been surface-treated to improve their dispersibility in liquids, making them ideal for use in inkjet inks and other liquid applications. There are also grades of titanium dioxide that have been treated to enhance their UV resistance, making them ideal for use in outdoor coatings and plastics.

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In a 2016 study published in Scientifica (Cairo), Egyptian researchers examined the effects of titanium dioxide nanoparticles on the organs of mice by orally administering the food additive daily, for five days. The results showed that the exposure produced “mild to moderate changes in the cytoarchitecture of brain tissue in a time dependent manner.” Furthermore, “Comet assay revealed the apoptotic DNA fragmentation, while PCR-SSCP pattern and direct sequencing showed point mutation of Presenilin 1 gene at exon 5, gene linked to inherited forms of Alzheimer’s disease.” The researchers wrote: “From these findings, “the present study concluded that TiO2NPs is genotoxic and mutagenic to brain tissue which in turn might lead to Alzheimer’s disease incidence.”

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